It's no secret they do take the weekends off. They are typically at the office and working 9AM - 9PM Pacific Time from Monday to Friday.
I'm from Canada and today is Thanksgiving for us, and I understand it's Columbus Day in the US as well.
That being said, I pinged the founders on Twitter this morning, and just got this:
To address the other points:
Refunds can always be requested by e-mail, just contact firstname.lastname@example.org
Shipping was delayed but has resumed as of a little while ago, see the Shipping Updates thread where @pmg explains what happened
To my knowledge, @cameron and @pmg are both full time dedicated to Lockitron and aren't going anywhere.